Ciba Foundation Symposium 135 - Novel Infectious Agents and by CIBA Foundation Symposium

By CIBA Foundation Symposium

The time period ``unconventional virus'' refers to virus-like brokers that range from traditional viruses in major respects--resistance to brokers that inactivate basic viruses, for instance. sure infrequent and deadly neurological issues, reminiscent of the Creutzfeldt-Jacob syndrome and the Gerstmann-Straussler syndrome, are essentially produced by means of virus-like infectious brokers, however the nature of those brokers isn't really understood. This quantity brings jointly the most recent details on one such affliction: Scrapie, a disorder taking place in sheep. It discusses the character of this infectious agent and insights won via new recommendations in molecular genetics. The paintings as a complete specializes in the results of animal facts for learn on human issues, equivalent to the prospective connection among unconventional viruses and Alzheimer's affliction. The discussions symbolize the paintings of experts from a huge spectrum of fields together with virology, neuropathology, and molecular biology.

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4. Dose-incubation curves of 139A scrapie in CW mice. Data from Fig. la in Kirnberlin et a1 (1987). p. c. infection. c. route (Kimberlin & Walker 1986a). Previously, we have suggested that the development of the fatal clinical disease depends on scrapie agent replicating and causing cell dysfunction (perhaps cell death) in a small number of so called 'clinical target areas' (CTA: see Kimberlin & Walker 1983). The major conclusion from all of the above studies is that the site of invasion (or injection) of the CNS affects the duration of the replication phase in brain by determining the neural pathways by which the CTA are reached (Kimberlin & Walker 1986a, Kimberlin et al 1987).

Let me quote Pat Merz’ original Neuropathology of unconventional virus infections 35 description of SAF (Merz et a1 1981): “SAF of type 1is a fibril comprised of two filaments. The fibrils are 12-16 nm in width with a space of 2-4 nm between the filaments. At their narrowest, the fibrils are 4-6 nm in width with no observable space between the two filaments. The fibrils narrow to 4-6 nm usually every 40-60 nm, although in some of the fibrils the narrowing is found every 80-110 nm. Within the fibril the space between the individual filaments can be observed for 40-60 nm along the length of the fibril between each narrow portion.

Experimentally, of course, we might also do it in primates. References Dickinson AG, Fraser H, Outram GW 1975Scrapie incubation time can exceed natural lifespan. Nature (Lond) 256:732-733 Fraser H, Dickinson AG 1985 Targeting of scrapie lesions and spread of agent via the retino-tectal projection. Brain Res 346:3241 Johnson RT, Mims CA 1968 Pathogenesis of viral infections of the nervous system. N Engl J Med 278:23-30, 84-92 Kim YS, Carp RI, Callahan SM, Wisniewski HM 1987 Incubation periods and survival times for mice injected stereotaxically with three scrapie strains in different brain regions.

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Ciba Foundation Symposium 135 - Novel Infectious Agents and by CIBA Foundation Symposium
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