Clusterin in Normal Brain Functions and During by Caleb Ellicott Finch

By Caleb Ellicott Finch

Clusterin is a multifunctional protein which was once independently came upon through greater than ten diversified study teams in the Eighties. New roles of clusterin in mind features have come to llight that are summarized right here through the researchers concerned. fresh discoveries contain a special lipoprotein particle containing clusterin and apoE secreted via astrocytes, and the power of clusterin to advertise neurotoxic actions of the amyloid beta peptide, but additionally to be neuroprotective. additionally integrated is contemporary information regarding clusterin and Alzheimer's illness. In all, this can be a accomplished and up to date assessment of clusterin within the mind.

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85 Most of these cells have been identified as small pyramidal neurons in layer III and some as large Clusterin and Apolipoprotein E Gene Expression in the Adult Brain 27 pyramidal cells in layer V, using double staining with a second antibody to the neuronal marker microtubule associated protein 2. 86 Together these results indicate that neuronal labeling in humans appears with increasing age. Alternatively, optimal sensitivity of the ICC method used in the last study may not have been reached, thereby not allowing for the detection of lower amounts of apoE in neurons.

21. Michel D, Gillet G, Volovitch M et al. 5 kD precursor protein is induced by different retroviral oncogenes in quail neuroretinals cells. Oncogene Res 1989; 4:127-36. 22. Lampert-Etchells M, McNeill TH, Laping NJ et al. Sulfated glycoprotein-2 is increased in rat hippocampus following entorhinal cortex lesioning. Brain Res 1991; 563:101-6. 23. Pasinetti GM, Cheng HW, Morgan DG et al. Astrocytic messenger RNA responses to striatal deafferentation in male rat. Neuroscience 1993; 53:199-211. 24.

20 During the estrous cycle, changes in apoJ levels are associated with uterine cell turnover and involution. In the mouse, apoJ increases in the lumenal epithelial cells during uterine involution through estrus and metestrus I. After ovariectomy (OVX), during the most intense periods of uterine atrophy, apoJ protein accumulates in the lumenal epithelial cells. 21 Steroids and Lipoproteins in the CNS Apolipoprotein E production in the adult rodent brain is also influenced by estrogen. Again, this effect is dependent upon genotype and varies between brain regions.

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Clusterin in Normal Brain Functions and During by Caleb Ellicott Finch
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