Course Guide by Bromley S., Brown W.

By Bromley S., Brown W.

This direction advisor serves as a consultant for either DU301 an international of Whose Making? and DU321 Making the foreign. The instructing fabrics and studying results for DU321 are similar to these for the 1st half DU301. in spite of the fact that, to ensure that this path advisor to be as transparent as attainable, we've separated it into parts:* scholars doing DU301 should still learn pages four to 18.* scholars doing DU321 should still learn pages 19 to 27.

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Ingestion can be of importance if hands are contaminated, as can swallowing respiratory secretions after inhalational exposure. Inhalation of dusts, gases, vapours and aerosols from the workplace air is an obvious way of exposure by breathing, while the dermal route is less obvious. There are examples of situations where repeated air monitoring shows undetectable levels of a chemical, while urinary monitoring continually presents positive results (see the MOCA exercise in Basics of toxicology 25 Chapter 17).

The toxicity of mixtures remains an issue as it is appreciated that people are exposed to many chemicals simultaneously and that the vast majority of toxicological data are on the individual chemicals. This presents a massive problem, as it would not be possible to test all permutations and combinations of chemicals to which humans may be exposed. Here there may be a role for in vitro systems as a screen for likely problem mixtures, although this is still to be realised. It does seem, however, that calculation of the toxicity of mixtures based on their individual ingredients is becoming used and accepted more often and that, usually, the calculated value has been found to be consistent with the toxicity when this has actually been determined.

The term ‘occupational’ is used in preference to ‘industrial’ because the latter may have the connotation of chemical exposure in factories; this would not necessarily include work such as farming, with potential exposure to pesticides—or office work, with issues such as photocopiers in enclosed spaces. Why is occupational toxicology required? There is considerable public awareness of the health effects of chemicals due to events such as the thalidomide tragedy and environmental contamination with chemicals.

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Course Guide by Bromley S., Brown W.
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