Metabolomics as a tool in nutritional research by Jean Louis Sébedio

By Jean Louis Sébedio

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On a practical level, such studies are limited to a small number of participants and are costly to run. More often, nutritional intervention studies are carried out in free-living populations and rely on the compliance of the participants to achieve accurate results. Given the inherent variation in human metabolite profiles, it is therefore essential to carry out a careful study design before embarking on any analysis. 8 Analytical methods Metabolomic analysis involves the qualitative and quantitative analysis of a diverse range of low-molecular mass compounds over a wide range of concentrations.

2012). 5 Functional foods The role of functional foods in promoting health and improving disease has gained attention from the scientific community and the media. Various claims concerning the efficacy or pre- and probiotics have been made and much of the literature is contradictory. Products such as yoghourts containing live bacteria, raw wheat bran, and inulin have become popular yet limited research has been carried out to substantiate the claims. , 2013). , 2013). Various hospitals promote the administration of pro- and prebiotics to patients postoperatively.

Metabolomics in systems biology. Annu. Rev. Plant Biol. 54, 669–689. , 2005. HPLC-MSbased methods for the study of metabonomics. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 817, 67–76. , 2007. Current progress in computational metabolomics. Brief. Bioinform. 8, 279–293. , 2008. The human cerebrospinal fluid metabolome. J. Chromatogr. B 871, 164–173. , 2013. 0—the human metabolome database in 2013. Nucleic Acids Res. 41, D801–D807. , 2013. New sample preparation approach for mass spectrometry-based profiling of plasma results in improved coverage of metabolome.

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Metabolomics as a tool in nutritional research by Jean Louis Sébedio
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