Organic Syntheses by Coffen D.L., Boeckman R.K., Overman L.E. (eds.)

By Coffen D.L., Boeckman R.K., Overman L.E. (eds.)

Show description

Read or Download Organic Syntheses PDF

Best organic chemistry books

Peptide and Protein Design for Biopharmaceutical Applications

Peptides function powerful medicinal drugs within the sanatorium this present day. but the inherent drawbacks of peptide constructions can restrict their efficacy as medicinal drugs. to beat this researchers are constructing new ways to create ‘tailor-made’ peptides and proteins with better pharmacological properties.

Design of Peptides and Proteins offers an outline of the experimental and computational tools for peptide and protein layout, with an emphasis on particular functions for therapeutics and biomedical study. issues coated include:
<ul type="disc">* computing device modeling of peptides and proteins* Peptidomimetics* layout and synthesis of cyclic peptides* Carbohydrates in peptide and protein layout* De novo layout of peptides and proteins* clinical improvement functions* a longer case learn – the layout of insulin variants

Design of Peptides and Proteins provides the state of the art of this intriguing method for therapeutics, with contributions from foreign specialists. it really is a necessary source for tutorial and commercial scientists within the fields of peptide and protein drug layout, biomedicine, biochemistry, biophysics, molecular modelling, artificial natural chemistry and medicinal/pharmaceutical chemistry.

Quality: Vector, Searchable, Bookmarked

Heteroatom Manipulation, Volume Volume 6

During this quantity, these useful teams containing heteroatoms that experience won value in natural synthesis are handled intimately. The creation of those a number of teams and their appropriate ameliorations are defined and a number of the points of chemoselectivity, regioselectivity and stereoselectivity are mentioned.

Additional resources for Organic Syntheses

Example text

Hiiro T, Kambe N, Ogawa A, Miyoshi N, Murai S, Sonoda N (1987) Angew Chem Int Ed Engl 26:1187 38. Amurrio D, Khan K, Kündig EP (1996) J Org Chem 61:2258 39. Kündig EP, Liu R, Ripa A (1992) Helv Chim Acta 75:2657 40. Nishimura K, Ono M, Nagaoka Y, Tomioka K (1997) J Am Chem Soc 119:12974; Tomioka K, Okuda M, Nishimura K, Manabe S, Kanai M, Nagaoka Y, Koga K (1998) Tetrahedron Lett 39:2141; Nishimura K, Ono M, Nagaoka Y, Tomioka K (2001) Angew Chem Int Ed 40:440; Nishimura K, Tomioka K (2002) J Org Chem.

Seebach D, Crass G, Wilka E-M, Hilvert D, Brunner E (1979) Helv Chim Acta 62:2695 30. Mukaiyama T, Soai K, Kobayashi S (1978) Chem Lett 219 31. Soai K, Mukaijama T (1978) Chem Lett 491 32. Mukaiyama T, Soai K, Sato T, Shimizu H, Suzuki K (1979) J Am Chem Soc 101:1455 34 Bernd Goldfuss 33. 34. 35. 36. 37. 38. 39. 40. 41. Mukaiyama T, Suzuki K (1980) Chem Lett 255 Johnson WS, Frei B, Gopalan AS (1981) J Org Chem 46:1512 Mazaleyat J-P, Cram DJ (1981) J Am Chem Soc 103:4585 Eleveld MB, Hogeveen H (1984) Tetrahedron Lett 25:5187 Arvidsson PI, Hilmersson G, Davidsson Ö (1999) Chem Eur J, 5:2348 Whitesell JK, Jaw B-R (1981) J Org Chem 46:2798 Colombo L, Gennari C, Poli G, Scolastico C (1982) Tetrahedron 38:2725 Alberts AH, Wynberg H (1989) J Am Chem Soc 111:7265 For an early report on the role of mixed aggregates see: Seebach D, Amstutz R, Dunitz JD (1981) Helv Chim Acta 64:2622 Ye M, Logaraij S, Jackman LM, Hillegass K, Hirsh KA, Bollinger AM, Grosz AL (1994) Tetrahedron 50:6109 Kang J, Kim JI, Lee JH (1994) Bull Korean Chem Soc 15:865 Corruble A, Valnot J-Y, Maddaluno J, Duhamel P (1997) Tetrahedron: Asymmetry 8:1519 Corruble A, Valnot J-Y, Maddaluno J, Duhamel P (1998) J Org Chem 63, 8266 Schön M, Naef R (1999) Tetrahedron: Asymmetry 10:169 Knollmüller M, Ferencic M, Gärtner P (1999) Tetrahedron: Asymmetry 10:3969 Aspinall HC, Dwyer JLM, Greeves N, Steiner A (1999) Organometallics 18:1366 Review on RLi/ROM compounds: Lochmann L (2000) Eur J Inorg Chem 1115 McGarrity JF, Ogle C A, Brich Z, Loosli H-R (1985) J Am Chem Soc 107:1810 Snieckus V (1990) Chem Rev 90:879 Hommes NJR v E, Schleyer P v R (1994) Tetrahedron 50:5903 Hommes NJR v E, Schleyer P v R (1992) Angew Chem 104:768; Angew Chem In Ed Engl 31:755 Goldfuss B, Schleyer P v R, Handschuh S, Hampel F (1998) J Organomet Chem 552:285 Activation via deaggregation of organolithiums by coordinating solvents (THF) or ligands (TMEDA) is frequently used in lithiations of hydrocarbons: Brandsma L, Verkruijsse H (1987) Preparative polar organometallic chemistry.

110. 111. 112. 113. 114. 115. 116. 35 Kottke T, Stalke D (1993) Angew Chem 105:619; Angew Chem Int Ed Engl 32:580 Briggs TF, Winemiller MD, Xiang B, Collum DB (2001) J Org Chem 66:6291 Sun X, Winemiller MD, Xiang B, Collum DB (2001) J Am Chem Soc 123:8039 Jiang B, Feng Y (2002) Tetrahedron Lett 43: 2975 Tzalis D, Knochel P (1999) Angew Chem 111:1547; Angew Chem Int Ed 38:1463 Frantz DE, Fässler R, Carreira E (2000) J Am Chem Soc 122:1806 Corey EJ, Guzman-Perez A (1998) Angew Chem 110:402, Angew Chem Int Ed 37:388 Wakefield BJ (1974) The chemistry of organolithium compounds.

Download PDF sample

Organic Syntheses by Coffen D.L., Boeckman R.K., Overman L.E. (eds.)
Rated 4.10 of 5 – based on 25 votes