The A-Z of Neurological Practice: A Guide to Clinical by Roger A. Barker, Neil Scolding, Dominic Rowe, Andrew J.

By Roger A. Barker, Neil Scolding, Dominic Rowe, Andrew J. Larner

It is a pocket-sized ready-reference to neurology. Organised from A to Z, the content material comprises a chain of entries, each describing, in a readable and available sort, a side of neurology. This levels from delivering overviews of significant teams of illnesses (e.g. the dementias) to extra exact assurance of particular sickness different types (e.g. Alzheimer's disease). particular neurological stipulations are defined in response to a truly established template overlaying the definition of the , its medical beneficial properties, research, pathogenesis and therapy, completing with a small variety of correct and updated references. additionally, there are tricks approximately differential analysis with broad go referencing among entries. it will develop into a necessary source for these project education in neurology, should be of curiosity to these with pursuits heavily allied to neurology (e.g. neurosurgery, neurorehabilitation) in addition to delivering a reference resource for generalists trying to find a readable synopsis of neurological stipulations.

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CSF: may show raised protein. Neurophysiology: often non-contributory, but may show peripheral neuropathy. Brain/meningeal biopsy: required for diagnosis. Differential diagnosis Isolated angiitis of the central nervous system. Behçet’s disease. Subacute viral encephalitis. Gliomatosis cerebri. CNS lymphoma. Treatment and prognosis The condition is usually fatal, possibly because it is diagnosed late. If detected early, treatment with chemotherapy and radiotherapy may be tried. Steroids may give a temporary benefit.

Neurogenetics: mutations in the gene encoding GFAP. 26 A Differential diagnosis Other leukodystrophies, especially Canavan’s disease. Enlarged head: Hydrocephalus (in juvenile cases) Canavan’s disease Glutaric aciduria type I Gangliosidoses Metachromatic leukodystrophy L-2-hydroxyglutaric acidaemia. Treatment and prognosis No specific treatment. Symptomatic measures for epilepsy, spasticity. The younger the onset the worse the prognosis. 5 years juvenile group ϳ8 years. References Borrett D, Becker LE.

Neurology in Clinical Practice (3rd edition). Boston: Butterworth-Heinemann, 2000: 1595–1664. Gascon GG, Ozand PT. Aminoacidopathies and organic acidopathies, mitochondrial enzyme defects, and other metabolic errors. ). Textbook of Clinical Neurology (2nd edition). Philadelphia: Saunders, 2003: 629–664. Menkes JH. Disorders of amino acid metabolism. ). Merritt’s Textbook of Neurology (9th edition). Baltimore: Williams & Wilkins, 1995: 538–546. Other relevant entries Canavan’s disease; Cystinosis; Hartnup’s disease; Homocystinuria; Lowe syndrome; Maple syrup urine disease; Non-ketotic hyperglycinaemia; Phenylketonuria; Tyrosinaemia.

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The A-Z of Neurological Practice: A Guide to Clinical by Roger A. Barker, Neil Scolding, Dominic Rowe, Andrew J.
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